Medicine

All Articles

Prenatal direct exposure to scarcity has an effect on long-lasting wellness

.Attribute Medicine, Posted online: 09 September 2024 doi:10.1038/ d41591-024-00068-4Analysis of inf...

An international metric of immune health and wellness

.Nature Medication, Posted online: 05 September 2024 doi:10.1038/ s41591-024-03210-4A research study...

Niacin, food consumption as well as heart effects

.Attribute Medication, Posted online: 05 September 2024 doi:10.1038/ s41591-024-03220-2Niacin, food ...

Opportunities and also obstacles for patient-reported end result analysis in multimorbidity investigation and also method

.Competing enthusiasms.S.E.H. acquires backing from the National Institute of Health and also Care R...

Hibernation science utilized to handle excessive weight and change metabolic process

.Attribute Medication, Posted online: 04 September 2024 doi:10.1038/ s41591-024-03226-wBy understand...

CAR- T and also mobile genetics therapies are also pricey

.Nature Medicine, Released online: 04 September 2024 doi:10.1038/ s41591-024-03231-zPoint-of-care pr...

The that genomics course of help reasonable execution of human genomics for international health

.The magazine of the initial draft of the human genome series in 20011 was observed due to the arriv...

A time-stratified, case\u00e2 $ \"crossover research study of heat exposure as well as perinatal death coming from 16 health centers in sub-Saharan Africa

.Amongst 138,015 hospital-based singleton births in 4 sub-Saharan African nations, our experts notic...

Advancing worldwide antibiotic investigation, progression and access #.\n\nMurray, C. J. L. et cetera. Worldwide trouble of bacterial antimicrobial resistance in 2019: a systematic review. Lancet 399, 629\u00e2 $ \"655 (2022 ). AMR Frontrunnerses. Towards particular commitments and also activity in the reaction to antimicrobial protection. Global Leaders Team on Antimicrobial Resistance https:\/\/www.amrleaders.org\/resources\/m\/item\/glg-report (4 April 2024). World Health Organization. WHO publishes list of micro-organisms for which new anti-biotics are actually quickly needed. Planet Health Organization https:\/\/www.who.int\/news\/item\/27-02-2017-who-publishes-list-of-bacteria-for-which-new-antibiotics-are-urgently-needed (27 February 2017). Globe Health Company. That microbial concern virus checklist, 2024: bacterial microorganisms of hygienics importance to lead investigation, advancement as well as techniques to prevent as well as regulate antimicrobial protection. Globe Health Company https:\/\/www.who.int\/publications\/i\/item\/9789240093461 (17 May 2024). Silver, L. L. A Gestalt way to Gram-negative entry. Bioorg. Medication. Chem. 24, 6379\u00e2 $ \"6389 (2016 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nSundqvist, M. Reversibility of antibiotic protection. Ups. J. Med. Sci. 119, 142\u00e2 $ \"148 (2014 ).\nGoogle.com Scholar\u00c2.\nWorld Health And Wellness Organization. 2023 anti-bacterial agents in medical and preclinical growth: an introduction as well as study. Globe Health and wellness Institution https:\/\/www.who.int\/publications\/i\/item\/9789240094000 (14 June 2024). O' Neill, J. et cetera. AMR Customer review. May 19, 2016 \u00e2 $\" Handling drug-resistant infections around the world: final document and suggestions. Evaluation on Antimicrobial Protection https:\/\/amr-review.org\/Publications.html (19 May 2016). Drive-AB Range. DRIVE-AB outcomes: files and rundown. Steer abdominal muscle https:\/\/drive-ab.eu\/drive-ab-outputs\/drive-ab-reports\/ (2016 ). Stern, S. et al. Breaking through the wall surface: a require concerted activity on anti-biotics trial and error. Boston ma Consulting Group https:\/\/www.bundesgesundheitsministerium.de\/fileadmin\/Dateien\/5_Publikationen\/Gesundheit\/Berichte\/GUARD_Follow_Up_Report_Full_Report_final.pdf (February, 2017). Anderson, M., Panteli, D. &amp Mossialos, E. Plan Brief 51: Exactly how can the EU assistance lasting development and also access to reliable antibiotics? plan options for existing and also brand new medications. International Observatory on Health And Wellness Systems as well as Policies https:\/\/eurohealthobservatory.who.int\/publications\/i\/how-can-the-eu-support-sustainable-innovation-and-access-to-effective-antibiotics-policy-options-for-existing-and-new-medicines (21 June 2023). Turnidge, J. &amp Christiansen, K. Anti-biotic usage and resistance\u00e2 $\" confirming the noticeable. Lancet 365, 548\u00e2 $ \"549 (2005 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nPlanet Wellness Company. 2021 Informed distinction. That get access to, watch, get, classification of prescription antibiotics for analysis and also monitoring of utilization. World Health and wellness Company https:\/\/www.who.int\/publications\/i\/item\/2021-aware-classification (30 September 2021). International Centre for Illness Avoidance as well as Control. Antimicrobial resistance aim ats: how can our experts reach them through 2030? ECDC https:\/\/www.ecdc.europa.eu\/sites\/default\/files\/documents\/amr-brief-eaad-2023-update.pdf (2023 ). Globe Health Association. Absence of innovation readied to weaken antibiotic efficiency and also health gains. World Wellness Company https:\/\/www.who.int\/news\/item\/22-06-2022-22-06-2022-lack-of-innovation-set-to-undermine-antibiotic-performance-and-health-gains (22 June 2022). Magnano San, L. R. et cetera. How antimicrobial resistance is linked to temperature improvement: a review of two linked global challenges. Int. J. Environ. Res. Public Health twenty, 1681 (2023 ). Article\u00c2.\n\nGoogle Scholar\u00c2.\nDolecek, C., Shakoor, S., Basnyat, B., Okwor, T. &amp Sartorius, B. Drug-resistant bacterial infections: our company need to have important action and investment that pay attention to the weakest web link. PLoS Biol. Twenty, e3001903 (2022 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nPlanet Health Organization. Booster shot insurance coverage. Globe Wellness Organization https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/immunization-coverage (15 July 2024). Chimhini, G., Magwenzi, M. &amp Fitzgerald, F. C. Disease prevention as well as control in low-resource settings: the necessity for the nearby, the contextual and also the practical. Corrupt. Prev. Pract. 4, 100135 (2022 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nNour, S., Stokle, E., Ashiru-Oredope, D. &amp Wesangulae, E. Difficulties of executing antimicrobial conservation devices in reduced to mid income nations (LMICs). Corrupt. Prev. Pract. 5, 100315 (2023 ). Article\u00c2.\n\nGoogle Scholar\u00c2.\nAminov, R. A quick past of the antibiotic age: lessons knew as well as challenges for the future. Front end. Microbiol. 1, 134 (2010 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nOutterson, K. et al. Individual get access to in 14 high-income countries to brand-new antibacterials permitted by the US Food and Drug Administration, European Medicines Company, Japanese Pharmaceuticals and Medical Devices Agency, or even Wellness Canada, 2010\u00e2 $ \"2020. Clin. Infect. Dis. 74, 1183\u00e2 $ \"1190 (2022 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nGlobe Health Company. 2021 antibacterial representatives in clinical as well as preclinical growth: a review and also analysis. Planet Wellness Organization https:\/\/www.who.int\/publications\/i\/item\/9789240047655 (27 May 2022). Prescription antibiotics: the business economics must sustain the scientific research. Nature 625, 7 (2024 ). Thomas, D. &amp Wessel, C. The condition of development in antibacterial therapies. Biotechnology Development Company https:\/\/www.bio.org\/sites\/default\/files\/2022-02\/The-State-of-Innovation-in-Antibacterial-Therapeutics.pdf (February, 2022). Strich, J. et cetera. Assessing medical professional utilization of next-generation prescription antibiotics versus resisting Gram-negative diseases in united state hospitals: a retrospective associate research. Ann. Intern. Med. 177, 559\u00e2 $ \"572 (2024 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nThomas, D. &amp Wessel, C. The state of technology in antibacterial rehabs. Biotechnology Technology Company https:\/\/www.bio.org\/sites\/default\/files\/2022-04\/BIO-Antibacterial-Report-2022.pdf (February 2022). Renwick, M. J., Brogan, D. M. &amp Mossialos, E. A step-by-step assessment and also important examination of motivation strategies for exploration and progression of unfamiliar prescription antibiotics. J. Antibiot. 69, 73\u00e2 $ \"88 (2016 ). Article\u00c2.\nCAS\u00c2.\n\nGoogle.com Scholar\u00c2.\nHealth Urgent Preparedness as well as Action Authorization. Research and development of health care countermeasures. International Commission https:\/\/health.ec.europa.eu\/health-emergency-preparedness-and-response-hera\/preparedness\/research-and-development-medical-countermeasures_en (2024 ). European Payment. Pre-draft proposition for an European relationship under Horizon Europe One Health And Wellness Antimicrobial Protection. International Commission https:\/\/research-and-innovation.ec.europa.eu\/system\/files\/2022-02\/ec_rtd_he-partnerships-onehealth-amr.pdf (9 February 2022). International Anti-biotic R &amp D Alliance. Entasis Rehabs and also the International Prescription Antibiotic Study &amp Growth Collaboration to cultivate a new treatment for gonorrhea. GARDP https:\/\/gardp.org\/entasis-therapeutics-and-the-global-antibiotic-research-development-partnership-to-develop-a-new-treatment-for-gonorrhea\/ (6 July 2017). Atal, I., Trinquart, L., Porcher, R. &amp Ravaud, P. Differential globalization of industry- as well as non-industry-sponsored clinical trials. PLoS ONE 10, e0145122 (2015 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nWorld Wellness Company. Number of medical trial signs up through place, disease, phase of advancement, age as well as sex of trial attendees (1999\u00e2 $ \"2022). World Health Association https:\/\/www.who.int\/observatories\/global-observatory-on-health-research-and-development\/monitoring\/number-of-trial-registrations-by-year-location-disease-and-phase-of-development (February 2023). International Anti-biotic R &amp D Alliance. NeoSept1: a research to identify the position of existing and also new anti-biotics mixtures to handle newborns who remain in hospital with extreme blood poisoning. ISRCTN computer registry https:\/\/www.isrctn.com\/ISRCTN48721236 (17 January 2022). Public Health Company of Canada. Government of Canada makes essential expenditure to fight antimicrobial protection (AMR), Authorities of Canada https:\/\/www.canada.ca\/en\/public-health\/news\/2023\/05\/government-of-canada-makes-important-investment-to-fight-antimicrobial-resistance-amr.html (11 May 2023). Worldwide Anti-biotic Trial And Error Relationship. Japan government funding supports GARDP\u00e2 $ s efforts to counter antibiotic protection. GARDP https:\/\/gardp.org\/japan-government-funding-supports-gardps-efforts-to-counter-antibiotic-resistance\/ (19 Oct 2023). Novo Nordisk Base. Novo Nordisk Structure partners along with CARB-X to overcome drug-resistant contaminations. novo nordisk groundwork https:\/\/novonordiskfonden.dk\/en\/news\/novo-nordisk-foundation-partners-with-carb-x-to-fight-drug-resistant-infections\/ (9 January 2024). International Commission: European Health And Wellness and also Digital Executive Agency. Research on bringing AMR medical countermeasures to the market. Publications Workplace of the European Union https:\/\/op.europa.eu\/en\/publication-detail\/-\/publication\/51b2c82c-c21b-11ed-8912-01aa75ed71a1\/language-en (2023 ). Outterson, K. Approximating the proper measurements of global pull motivations for antibacterial medications. Wellness Aff. 40, 1758\u00e2 $ \"1765 (2021 ). Article\u00c2.\n\nGoogle.com Scholar\u00c2.\nEvans, E. J., Meyer, A. &amp Conti, R. M. Sizing a market entrance reward for the growth of brand new antibiotics. Harvard Kennedy College https:\/\/www.hks.harvard.edu\/sites\/default\/files\/centers\/mrcbg\/Final_AWP_232.pdf (May 2024). Morel, C. M. et al. Sector motivations as well as antibiotic protection: an introduction to the antibiotic susceptibility bonus. J. Antibiot. 73, 421\u00e2 $ \"428 (2020 ). CAS\u00c2.\n\nGoogle.com Scholar\u00c2.\nBonnifield, R. &amp Towse, A. A determined USG progressed dedication for subscription-based getting of unique antimicrobials and its own anticipated roi. Facility for Global Advancement https:\/\/www.cgdev.org\/publication\/ambitious-usg-advanced-commitment-subscription-based-purchasing-novel-antimicrobials (15 Nov 2022). Towse, A. &amp Silverman Bonnifield, R. G7 investments in brand-new anti-biotics would certainly pay \u00e2 $\" for everybody. Office of Health Economics https:\/\/www.ohe.org\/insight\/g7-investments-in-new-antibiotics-would-pay-off-for-everyone\/ (9 December 2022). NHS England. NHS boosts war versus deadly infections complying with successful world-first aviator. NHS England https:\/\/www.england.nhs.uk\/2023\/07\/nhs-steps-up-battle-against-life-threatening-infections-following-successful-world-first-pilot\/ (11 July 2023). United States Our lawmakers. S. 1355 \u00e2 $\" PASTEUR Act of 2023. congress.gov www.congress.gov\/bill\/118th-congress\/senate-bill\/1355#:~:text=This%20bill%20authorizes%20the%20Department,and%20contains%20other%20related%20provisions (27 April 2023). European Percentage. Reform of the EU pharmaceutical legalisation. International Percentage https:\/\/health.ec.europa.eu\/medicinal-products\/pharmaceutical-strategy-europe\/reform-eu-pharmaceutical-legislation_en (26 April 2023). Gotham, D. et cetera. Repayment models to attack market failures for antimicrobials: approaches consumed France, Germany, Sweden, the United Kingdom, as well as the USA. Wellness Plan 125, 296\u00e2 $ \"306 (2020 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nInternational Federation of Drug Manufacturers and Affiliations. Coming from resistance to resilience: what could the future antibiotic pipe seem like? IFMPA https:\/\/www.ifpma.org\/publications\/from-resistance-to-resilience-what-could-the-future-antibiotic-pipeline-look-like\/ (14 May 2024). Global AMR R&ampD Center &amp Planet Health And Wellness Association. Incentivising the advancement of brand new antibacterial treatments: 2023 report card due to the Worldwide AMR R&ampD Center and WHO. Worldwide AMR R&ampD Center https:\/\/globalamrhub.org\/publications\/incentivising-the-development-of-new-antibacterial-treatments-2023\/ (2023 ). Glover, R. E., Performer, A., Roberts, A. P. &amp Kirchhelle, C. Why is the UK registration design for antibiotics thought about prosperous? Lancet Micro organism 4, e852\u00e2 $ \"e853 (2023 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nNon-paper \u00e2 $\" unique stimulations for the advancement as well as continuing the market of antimicrobials. Politician https:\/\/www.politico.eu\/wp-content\/uploads\/2022\/12\/01\/Non-paper-Transferable-exclusivity-voucher-for-AMR-2.pdf (2022 ). Liu, L. et cetera. Global, local, and also national reasons for youngster mortality in 2000\u00e2 $ \"13, with forecasts to update post-2015 top priorities: an upgraded step-by-step review. Lancet 385, 430\u00e2 $ \"440 (2015 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nQuadri, F. et cetera. Antibacterial drug deficiencies from 2001 to 2013: implications for professional application. Clin. Affect. Dis. 60, 1737\u00e2 $ \"1742 (2015 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nBenhabib, A. et cetera. The French coverage device for medication lacks: description and patterns coming from 2012 to 2018: an observational retrospective study. BMJ Open 10, e034033 (2020 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nKlein, E. Y. et al. Examination of that antibiotic usage and gain access to targets in 76 nations, 2000\u00e2 $ \"15: an analysis of pharmaceutical purchases information. Lancet Infect. Dis. 21, 107\u00e2 $ \"115 (2021 ). Article\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nPyzik, O. Z. &amp Abubakar, I. Fighting the fakes: tackling shoddy as well as falsified medicines. Nat. Rev. Dis. Guides 8, 55 (2022 ). Hayhoe, B., Greenfield, G. &amp Majeed, A. Is it acquiring simpler to get anti-biotics in the UK? Br. J. Gen. Pract. 69, 54\u00e2 $ \"55 (2019 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nAfrican Culture for Research Laboratory Medicine. Policy concise and infographics on antimicrobial resistance (AMR) in Africa. ASLM https:\/\/aslm.org\/resource\/policy-brief-and-infographics-on-antimicrobial-resistance-amr-in-africa\/ (14 September 2022). Kanu, J. S. et al. National antibiotic usage for human make use of in Sierra Leone (2017\u00e2 $ \"2019): a cross-sectional research. Trop. Medication. Corrupt. Dis. 6, 77 (2021 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nNamugambe, J. S. et al. National antimicrobial usage: study of main stockrooms materials to in-patient care wellness locations from 2017 to 2019 in Uganda. Trop. Medication. Corrupt. Dis. 6, 83 (2021 ).\nGoogle Scholar\u00c2.\nRobertson, J. et al. Variants in the usage of antimicrobial medications in the European location, 2014\u00e2 $ \"2018: searchings for and ramifications from ESAC-Net and also WHO Europe. Front. Pharmacol. 12, 639207 (2021 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nShukar, S. et al. Medication deficiency: sources, effect, and mitigation strategies. Face. Pharmacol. 12, 693426 (2021 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle Scholar\u00c2.\nOutterson, K., Orubu, E. S. F., Rex, J., \u00c3 ... rdal, C. &amp Zaman, M. H. Patient access in 14 high-income nations to new antibacterials accepted by the United States Fda, European Medicines Organization, Japanese Pharmaceuticals as well as Medical Instruments Organization, or even Wellness Canada, 2010\u00e2 $ \"2020. Clin. Affect. Dis. 74, 1183\u00e2 $ \"1190 (2021 ). Article\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nPulcini, C. et al. Wasted prescription antibiotics: a follow-up inventory research in Europe, the U.S.A., Canada as well as Australia. Int. J. Antimicrob. Representatives 49, 98\u00e2 $ \"101 (2017 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\n\nGoogle Scholar\u00c2.\nRottingen, J. A. &amp Farrar, J. Targeted health advancement for global health. Br. Medication. J. 366, 15601 (2019 ).\nGoogle.com Scholar\u00c2.\nAMR Field Partnership. The 2023 AMR Business Alliance progression survey: production and the environment. amr Field Partnership https:\/\/www.amrindustryalliance.org\/wp-content\/uploads\/2023\/12\/AMRIA_Manufacturing-and-the-environment-FINAL.pdf (2023 ). Munoz, V., Visentin, F., Venture, D. &amp Gaule, P. Can medical items be created on a charitable manner? Discovering item development collaborations for overlooked illness. Sci. Public Policy 42, 315\u00e2 $ \"338 (2015 ). Article\u00c2.\n\nGoogle Scholar\u00c2.\nSwaminathan, S. et cetera. Reboot biomedical R&ampD in the global public passion. Attribute 602, 207\u00e2 $ \"210 (2022 ). Article\u00c2.\nCAS\u00c2.\nPubMed\u00c2.\n\nGoogle.com Scholar\u00c2.\nAfrica Centres for Condition Command and also Protection. Africa CDC leads daring move to secure Africa\u00e2 $ s health future by creating a fifty billion buck medical market. AfricaCDC https:\/\/africacdc.org\/news-item\/africa-cdc-spearheads-bold-move-to-secure-africas-health-future-by-creating-a-50-billion-dollar-medical-market\/ (19 February 2024). Gore, C., Morin, S., R\u00c3 \u00b8 ttingen, J. A. &amp Kieny, M. P. Arranging public-health copyright licensing arrangements to improve access to wellness innovations: an insider\u00e2 $ s story. BMJ Glob. Health 8, e012964 (2023 ). Article\u00c2.\nPubMed\u00c2.\nPubMed Central\u00c2.\n\nGoogle.com Scholar\u00c2.\nSuleman, F., Low, M., Moon, S. &amp Morgan, S. G. New organization styles for r &amp d along with cost criteria are actually needed to attain fair pricing of medicines. Br. Med. J. 368, l4408 (2020 ). Article\u00c2.\n\nGoogle.com Scholar\u00c2.\nCombating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator. Conservation and also get access to. CARB-X https:\/\/carb-x.org\/about\/stewardship-and-access\/ (2024 ). Global Anti-biotic Research and Development Collaboration. Shinogi, GARDP and CHAI introduce site permit and cooperation arrangements to handle microbial contaminations by growing access to cefiderocol in 135 nations. GARDP https:\/\/gardp.org\/shionogi-gardp-and-chai-announce-landmark-license-and-collaboration-agreements-to-treat-bacterial-infections-by-expanding-access-to-cefiderocol-in-135-countries\/ (15 June 2022). AMR Market Partnership. Leaving behind the lab: tracking the decrease in AMR R&ampD professionals. amr Field Partnership https:\/\/www.amrindustryalliance.org\/wp-content\/uploads\/2023\/02\/Leaving-the-Lab_final-1.pdf (February, 2024). G7 Wellness Ministers. G7 Health Ministers\u00e2 $ Communiqu\u00c3 \u00a9. G7 Germany www.g7germany.de\/resource\/blob\/974430\/2042058\/5651daa321517b089cdccfaffd1e37a1\/2022-05-20-g7-health-ministers-communique-data.pdf (twenty May 2022). G20. G20 phone call to action on antimicrobial protection. G7G20 Documents Data bank https:\/\/g7g20-documents.org\/database\/document\/2022-g20-indonesia-sherpa-track-health-ministers-ministers-annex-g20-call-to-action-on-antimicrobial-resistance (28 Oct 2022). Worldwide Union on Aging &amp Transmittable Health Conditions Community of America. 2024 AMR preparedness index report card. Evaluating government activity on AMR plan. International Union on Aging https:\/\/globalcoalitiononaging.com\/wp-content\/uploads\/2024\/01\/2024-AMR-Index-Progress-Report.pdf (2024 ). Food Items and Horticulture Institution of the United Nations, United Nations Environment Program, World Health And Wellness Association &amp. Planet Organisation for Animal Health. International data source for tracking antimicrobial resistance (AMR): nation self-assessment survey (TrACSS). That https:\/\/amrcountryprogress.org\/

/map-viewindicator2.3 (2023 ). Vehicle Katwyk, S. R. &amp Outterson K. Intro: AMR belongs in the wid...

Integrating liver endpoints in scientific tests of heart and also kidney disease

.Nature Medication, Released online: 03 September 2024 doi:10.1038/ s41591-024-03223-zThis Standpoin...